the aim of this study was to evaluate the immune system and lymphocyte function in 41 iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. the patients consisted of 20 splenectomized and 21 non-splenectomized patients. they were treated with desferal, and had received repeated blood transfusion. laboratory investigations included measurement of total t lymphocytes, a...

This paper presents the use of a genetic programming (GP) system called STROGANOFF and a multilayer perceptron for thalassemic patient classification. The interested problem covers the test samples from normal subjects and that from different types of thalassemic patient and thalassemic trait. The features, which are the characteristics of red blood cell, Thalassemic Patient Classification Usin...

To further define the nature of abnormal iron deposits on the membranes of pathologic red blood cells, we have used sickle cell anemia (HbSS), HbSC, and @-thalassemic erythrocytes (RBCs) to prepare inside-out membranes (IOM) and insoluble membrane aggregates (AGGs) containing coclustered hemichrome and band 3. Study of IOM from HbSC and thalassemic patients showed that amounts of heme iron and,...

Objective: This study aimed to evaluate oral hygiene status, salivary fluoride concentration, and Streptococcus mutans Lactobacillus levels in saliva of thalassemic, hemophilic individuals without any other systemic disorders.Materials Methods: A total 162 (44 healthy individuals, 86 thalassemic 32 patients) were selected, randomly (n=30 each group), the patients allocated Group A: condition, B...

Background: Retarded growth in thalassemic patient is complex and multi-factorial, it includes chronic hypoxia secondary to anemia when pre-transfusion haemoglobin below 9 g/dl. Development of sexual characteristics children markedly delayed as compared their non-thalassemic siblings the expected development criteria due iron overload. The main objective present study monitor these patients lon...

This study designed to analyzed humoral response related to measuring the serum levels of immunoglobulines (IgG , IgM and IgA) and complements corporeats ( C3 and C4) in (20) thalassemic patient and (10) control subject. IgG only recorded a high significant differences between two studied group – whereas no significant differences were found in levels of remaining humoral components ( IgM , IgA...

To further define the nature of abnormal iron deposits on the membranes of pathologic red blood cells, we have used sickle cell anemia (HbSS), HbSC, and beta-thalassemic erythrocytes (RBCs) to prepare inside-out membranes (IOM) and insoluble membrane aggregates (AGGs) containing coclustered hemichrome and band 3. Study of IOM from HbSC and thalassemic patients showed that amounts of heme iron a...

Previous studies of beta-thalassemic reticulocytes have implied a decreased amount of functional beta-mRNA but unimpaired translation of the beta-mRNA present. However, the beta/alpha synthetic ratios in beta-thalassemic marrow are higher than those observed in reticulocytes of the same patients. This could imply that marrow cells contain an abnormally functioning beta-mRNA no longer active in ...

A cross sectional study was carried out at various hospitals of Faisalabad city. The aim of current study was to investigate the prevalence of β-thalassemia disease in hospital population related to age, consanguinity and anti-HCV antibody positivity. For this purpose, 300 patients were interviewed for the different parameters including specific type of β-thalassemia disease, their family histo...